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marijuana will improve the level or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.lumefantrine will lessen the extent or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.buprenorphine, lengthy-acting injection and diazepam both raise sedation. Stay